Effect of intracoronary prostaglandin E1 injection prior to percutaneous coronary intervention on myocardial microcirculation perfusion and clinical outcome in acute non-ST segment elevation myocardial infarction
10.3760/cma.j.issn.1008-6706.2018.04.004
- VernacularTitle:冠状动脉内注射前列腺素E1对急性非ST段抬高型心肌梗死早期介入术后心肌微循环及预后的影响
- Author:
Jun JI
1
;
Shenghu HE
;
Shu CHEN
;
Rixin XU
;
Xiaodong LIU
;
Qingchi LIAO
;
Bing XU
;
Jing ZHANG
;
Jianqiu ZHANG
Author Information
1. 江苏省苏北人民医院心内科
- Keywords:
Myocardial infarction;
Myocardial perfusion imaging;
Prostaglandin E1
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(4):419-423
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the clinical effects and the major adverse cardiac events of intracoronary prostaglandin E1 injection prior to percutaneous coronary intervention (PCI) in early(within 24h of symptom onset) interventional treatment for patients with acute non -ST segment elevation myocardial infarction ( NSTEMI ) . Methods 122 patients with NSTEMI who underwent early interventional treatment were divided into three groups according to the digital table:41 cases in prostaglandin E 1 group,41 cases in nitroglycerin group ,40 cases in control group.The TIMI blood flow was compared among the three groups after PCI .All patients were followed up during 6 months about major adverse cardiac events ( MACE) and the cardiac structure and function by echocardiography . Results After primary PCI,the corrected TIMI frame count(CTFC) was significantly better in the prostaglandin E 1 group[(20.22 ±6.82)] than in the nitroglycerin group[(26.35 ±8.71)] and the control group[(27.02 ±9.65), t=6.451,6.763,all P<0.05].The TIMI myocardial perfusion grade (TMP) was significantly better in the prosta-glandin E1 group(7.3％) than in the nitroglycerin group(26.8％) and the control group(30.0％)(P<0.05). There was no statistically significant difference between the nitroglycerin group and the control group (P>0.05).All patients were followed up for 6 months,the LVDd in the prostaglandin E1 group[(46.8 ±3.7)mm] was significantly lower than that in the nitroglycerin group[(49.5 ±5.8) mm] and the control group [(50.2 ±4.9) mm,t=6.312, 5.893,all P<0.05].The LVEF in the prostaglandin E1 group [(55.8 ±8.2)％] was significantly higher than that in the nitroglycerin group [(49.3 ±7.9)％] and the control group [(50.5 ±6.8)％,t=7.011,5.981,all P<0.05].The incidence rate of MACE in the prostaglandin E 1 group(4.9％) was significantly lower than that in the nitroglycerin group(12.2％) and control group(12.5％)(χ2 =5.834,5.719,all P<0.05).There was no statistically significant difference between the nitroglycerin group and the control group (P>0.05).Conclusion Intracoronary administration of prostaglandin E 1 injection prior to balloon dilation can significantly improve the myocardial microcir-culation perfusion,and can decrease MACE in patients with NSTEMI who underwent early interventional treatment .
