Correlation analysis of drug resistance of Salmonella and enterotoxin genes in 132 children with diarrhea in Taizhou area
10.3760/cma.j.issn.1008-6706.2018.03.023
- VernacularTitle:浙江省台州市儿童腹泻132例沙门菌耐药性检测及肠毒素基因的相关分析
- Author:
Yao HUANG
1
;
Lingling CHEN
;
Weimin LU
Author Information
1. 浙江省台州医院儿内科
- Keywords:
Diarrhea;
Salmonella infections;
Drug resistance,bacterial;
Enterotoxin gene
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(3):356-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the drug resistance of Salmonella and enterotoxin gene in diarrhea children of Taizhou.Methods 132 children with Salmonella infection who had fever ,diarrhea and other symptoms and were confirmed by fecal culture were selected .The Salmonella serotype , drug resistance analysis of 10 kinds of antibiotics,and enterotoxin gene (spvA,spvB,rck) were detected.Results 132 cases of Salmonella isolated from blood serological were identified a total of 10 serotypes,Salmonella typhimurium and Salmonella Enteritidis were the most common.In 132 strains of Salmonella ,the highest drug resistance rate was to ampicillin (51.82％) and ampicil-lin/sulbactam(51.52％),and had no resistance to imipenem ,ertapenem.In 132 strains of Salmonella,including sin-gle drug resistance of 27 strains(20.45％),the rest had two or more drugs resistance .In 132 strains of Salmonella, 132 strains were spvA positive(positive rate 100％),38 cases were spvB positive(positive rate 28.79％),45 cases were rck positive(positive rate 34.09％).The incidence rates of fever,dehydration and hematochezia in spvB positive children were significantly higher than those in spvB negative children (χ2 =6.022,6.661,6.978,all P<0.05).The incidence rates of fever and hematochezia in rck positive children were significantly higher than those in rck negative children (χ2 =9.134,12.673,all P<0.05).Conclusion Salmonella infection diarrhea children in the Taizhou area are mainly Salmonella typhimurium and Salmonella enteritidis infection ,the strains are highly resistant strains , enterotoxin spvB gene is correlated with the incidence rates of fever ,dehydration and hematochezia ,and rck gene is correlated with the incidence rates of fever and hematochezia .
