Effect of chemotherapy of DC combined with cinobufacini in the treatment of advanced stomach cancer
10.3760/cma.j.issn.1008-6706.2018.03.014
- VernacularTitle:华蟾素联合DC化疗方案治疗晚期胃癌临床观察
- Author:
Xiangnong XIAO
1
;
Chaohui LIN
;
Quan LI
;
Zhijie LIN
;
Haibin XIAO
Author Information
1. 泉州医学高等专科学校附属人民医院肿瘤科
- Keywords:
Stomach neoplasms;
Pharmaceutical drug;
Cinobufacini
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(3):322-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of the combination of cinobufacini with DC chemo-therapy in the treatment of advanced stomach cancer .Methods 65 patients who were diagnosed advanced gastric cancer on the basis of histocytology and pathology results , were randomly divided into DC chemotherapy group (31 cases) and combined treatment group (34 cases).The clinical curative effect ,adverse reaction,quality of life ( KPS questionnaire ) and the easement rate of pain were analyzed .Results The two groups had no statistically significant differences in adverse reaction (t=-0.0047,P>0.05) and clinical curative effect (χ2 =0.077,P>0.05),and the clinical response rate of the combined treatment group (35％) was similar to the DC chemotherapy group (32％).Besides,the easement rate of pain in the combined treatment group increased to 71％,which in the DC chemotherapy group increased to 45％(χ2 =19.969,P<0.05).And the improvement rate of quality of life (QOL) in the combined treatment group was 82％,which of the DC chemotherapy group was 55％,the difference was statistically significant(χ2 =13.923,P<0.05).Conclusion Cinobufaconi combined with DC chemotherapy in the treatment of advanced stomach cancer has no significant effect on increase of short -term efficacy ,but it can improve quality of life and alleviate pain obviously .
