Effect of ganglioside combined with hyperbaric oxygen on mild to moderate craniocerebral trauma and its influence on serum NSE and MBP levels
10.3760/cma.j.issn.1008-6706.2018.02.024
- VernacularTitle:神经节苷脂联合高压氧治疗轻中度颅脑外伤的疗效及对血清神经元特异性烯醇化酶和髓鞘碱性蛋白水平的影响
- Author:
Yankai XU
1
;
Cheng LUO
;
Shaoling MA
;
Shengliang XU
;
Jin WU
Author Information
1. 汕头大学医学院第一附属医院神经外科
- Keywords:
Craniocerebral trauma;
Gangliosides;
Hyperbaric oxygenation
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(2):225-228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of ganglioside combined with hyperbaric oxygen on mild to moderate craniocerebral trauma , and its effect on serum neuron specific enolase ( NSE ) and myelin basic protein ( MBP) levels.Methods Following the random number table method ,110 patients with mild and moderate cranioce-rebral trauma were randomly divided into the observation group and the control group ,55 cases in each group.The observation group was treated with ganglioside combined with hyperbaric oxygen therapy ,while the control group was treated with hyperbaric oxygen alone .The clinical efficacy ,the Glasgow Coma Scale ( GCS) ,the levels of serum NSE and MBP before and after treatment were compared between the two groups .Results The effective rate of the observation group was 94.55％,which was significantly higher than 81.82％ of the control group,the difference was statistically significant(χ2 =4.274,P<0.05).The D-value of GCS before and after treatment in the observation group was (2.97 ±0.59)points,which was significantly higher than that of control group (t=17.601,P<0.05). The levels of serum NSE and MBP of the observation group were significantly lower than those of the control group ( t=14.674,10.450,all P<0.05).Conclusion Ganglioside combined with hyperbaric oxygen can promote the recovery of neurological function ,has significant effect and high safety in the treatment of mild to moderate craniocerebral trauma .
