Clinical effect of methylprednisolone combined with methotrexate in the treatment of Graves ' ophthalmopathy
10.3760/cma.j.issn.1008-6706.2018.02.009
- VernacularTitle:甲泼尼龙联合甲氨蝶呤治疗Graves眼病的临床效果观察
- Author:
Jun CHEN
1
;
Jiao HUANG
;
Qianfang HUANG
;
Dahui WANG
Author Information
1. 杭州市萧山区第一人民医院内分泌科
- Keywords:
Methylprednisolone;
Methotrexate;
Graves ophthalmopathy;
Comparative effectiveness research
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(2):167-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective The effect and application value of the treatment of Graves eye disease were discussed.Methods 82 patients with Graves ophthalmopathy were divided into observation group and control group by random number method . The control group was given hormone therapy , the observation group was given methylprednisolone combined with methotrexate therapy .The clinical effect was compared between the two groups . Results The total effective rate of the observation group was 87.80％,which was significantly higher than 68.29％of the control group(χ2 =4.555,P<0.05).After treatment,the thyroid volume,eye level of the observation group were (24.68 ±1.25) g,(17.13 ±1.01) mm,respectively,which of the control group were (28.84 ±2.89) g, (18.79 ±2.12)mm,respectively,and the differences between the two groups were statistically significant (t=8.459, 4.526,all P<0.05).In the observation group,there were 2 cases of diabetes,1 case of hypertension,4 cases of insomnia,4 cases with digestive tract.In the control group,1 case of diabetes,2 cases of hypertension,5 cases of insomnia,3 cases of gastrointestinal tract ,and the differences between the two groups were not statistically significant (χ2 =0.346,0.346,0.124,0.156,all P>0.05).Conclusion Methylprednisolone combined with methotrexate in the treatment of Graves ophthalmopathy can improve the treatment effect , reduce the degree of exophthalmus and thyroid volume,and without increase in adverse reactions ,it is worthy of popularization and application in clinic .
