Expression and clinical significance of serum interleukin -33 in patients with chronic severe hepatitis B

VernacularTitle:慢性乙型肝炎患者血清白细胞介素-33的表达及临床意义
Author: Li XIN ¹ ; Yong DENG ; Zihui QIU ; Shuqiang OU
Author Information

1. 萍乡市第二医院感染科
Keywords: Hepatitis B; Interleukin
From: Chinese Journal of Primary Medicine and Pharmacy 2018;25(2):144-146
CountryChina
Language:Chinese
Abstract: Objective To explore the changes of interleukin -33 in serum of patients with chronic severe hepatitis B.Methods 25 patients with mild chronic hepatitis B ( MCHB group) and 25 patients with severe chronic hepatitis B(SCHB group) were collected.18 healthy people were collected as control (HC group).ELISA method was used to detect IL -33 level in peripheral blood .Results The IL-33 levels in MCHB and SCHB group were (11.7 ±6.9)ng/L and (16.5 ±9.1)ng/L,respectively,which were significantly higher than (5.1 ±2.9)ng/L in HC group(t=4.037,5.434,P=0.000,0.000).The IL-33 level in MCHB group was lower than that in SCHB group(t=2.108,P=0.040).The IL-33 level was positively correlated with ALT ,AST and HBV DNA(r=0.526, 0.568,0.285,P=0.000,0.000,0.045 ).Conclusion IL -33 is involved in the pathogenesis of hepatitis B . IL-33 plays an important role in HBV -relate injury.