Clinical distribution and antimicrobial resistance of carbapenem-resistant Enterobacteriaceae in Dongguan
10.3969/j.issn.1671-9638.2017.11.011
- VernacularTitle:东莞地区耐碳青霉烯类肠杆菌科细菌的临床分布及耐药性
- Author:
Zhu-Sheng GUO
1
;
Guo-Bin HUANG
;
Ji-Hua HU
;
Li ZHANG
;
Si-Si LIN
;
Shu-Jin XIE
;
Gui-Ling CHEN
;
Sen FENG
;
Jing ZHOU
;
Xue-Hai ZHU
;
Mou-Qing ZHOU
;
Zhen-Gang LIANG
Author Information
1. 中山大学附属东华医院
- Keywords:
carbapenem-resistant Enterobacteriaceae;
antimicrobial agent;
antimicrobial susceptibility testing;
drug resistance
- From:
Chinese Journal of Infection Control
2017;16(11):1040-1043
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical distribution and antimicrobial resistance of carbapenem-resistant Enterobacteriaceae (CRE) in Dongguan.Methods CRE isolated from hospitalized patients in 22 secondary and above medical institutions which participated in bacterial monitoring in Dongguan between January 2015 and June 2016 were retrospectively analyzed,antimicrobial resistance was analyzed by WHONET 5.6 software.Results A total of 71 CRE isolates were detected,with a isolation rate of 0.34％ (71/20 713).53 strains(74.65％) of CRE were isolated from patients aged 15-60 years old;46 (64.79 ％) were from male patients;CRE were mainly isolated from patients in intensive care unit(36 strains,50.70 ％);the main specimen was sputum(34 strains,47.89 ％),followed by urine (11 strians,15.49 ％) and wound secretion(6 strains,8.45 ％);the main infection type was healthcare associated infection (64 strains,90.14 ％);CRE were mainly distributed in tertiary hospitals(56 strains,78.87 ％),the isolation rate of CRE in tertiary and secondary hospitals were 0.41 ％(56/13 677)and 0.21％(15/7 036) respectively.71 strains of CRE were all resistant to imipenem,resistance rate to meropenem was 81.12％,only amikacin and tobramycin had drug resistance rates of ＜40％ (21.38％ and 38.79％ respectively),resistance rate to trime thoprim/sulfamethoxazole was 48.23 ％,while resistance rates to fluoroquinolones,third-generation cephalosporins,and enzyme inhibitors were all＞60.Conclusion The isolation rate of CRE in Dongguan is lower than that of the whole nation and the other provinces,effective prevention and control measures should be taken according to the key population and departments that isolated CRE,antimicrobial use should be rational.
