Healthcare-associated infection and drug resistance of Acinetobacter baumannii in neonatal intensive care units
10.3969/j.issn.1671-9638.2017.11.006
- VernacularTitle:NICU鲍曼不动杆菌的医院感染与耐药性分析
- Author:
Lu ZHUANG
1
;
Sheng ZHANG
;
Jie SONG
;
Yu-Pei ZHANG
;
Xiu-Juan WEI
;
Xian XIA
;
Qing-Bin LU
;
Qiu-Ping LI
;
Zhi-Chun FENG
Author Information
1. 陆军总医院附属八一儿童医院
- Keywords:
neonatal intensive care unit;
Acinetobacter baumannii;
healthcare-associated infection;
drug resistance
- From:
Chinese Journal of Infection Control
2017;16(11):1016-1020
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and antimicrobial resistance of Acinetobacter baumannii(A.baumannii) in neonatal intensive care units (NICUs).Methods The clinical isolation and antimicrobial resistance of A.baumannii causing healthcare-associated infection(HAD in 4 NICUs of a hospital from October 2012 to October 2014 were analyzed statistically.Results A total of 11 640 neonates were admitted in 4 NICUs,500(4.3 ％) developed HAI,51 (10.2 ％) developed 52 cases of A.baumannii infection.Distribution of A.baumannii infection was as follows:NICU of extremely premature infants,premature infants,full-term infants,and surgical NICU were 42,1,4,and 5 cases respectively.Incidences of A.baumannii HAI in 4 seasons were compared,difference was statistically significant(x2 =16.05,P＜0.05),infection mainly occurred in the spring and summer.A.baumannii had high resistance rates to β-1actam antibiotics (such as piperacillin/sulbactam,cefepime,imipenem)and gentamycin(＞90 ％),resistance rate to amikacin was the lowest (51.9 ％).Among 52 strains of A.baumannii,46 were multidrug-resistant strains,and 3 were extensively drug-resistant strains.Conclusion A.baumannii HAI is most serious in NICU of extremely premature infants,resistance rates to commonly used antimicrobial agents are high.
