Diagnostic value of procalcitonin, erythrocyte sedimentation rate, and C-reactive protein in intracranial infection after craniocerebral surgery in patients in intensive care unit
10.3969/j.issn.1671-9638.2017.11.004
- VernacularTitle:降钙素原、血沉、C反应蛋白对ICU颅脑术后患者颅内感染的诊断价值
- Author:
Yao LIU
1
;
Yi WANG
;
Xiang-You YU
Author Information
1. 新疆医科大学第一附属医院，新疆乌鲁木齐830054
- Keywords:
procalcitonin;
erythrocyte sedimentation rate;
C-reactive protein;
neurosurgical operation;
intracranial infection
- From:
Chinese Journal of Infection Control
2017;16(11):1008-1011
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value and clinical significance of serum procalcitonin (PCT),erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP) in intracranial infection after craniocerebral surgery in patients in intensive care unit(ICU).Methods 21 patients who were admitted to the ICU in a hospital between June 2011 and January 2016 were as infection group,42 patients without intracranial infection after craniocerebral surgery during the same period were as control group.Levels of PCT,ESR,and CRP in two groups were detected and analyzed statistically.Results Differences in age,gender,average body mass index,types of craniocerebral diseases,and postoperative indwelling drainage between infection group and control group were all not statistically significant (all P＞0.05).Patients with elevated serum PCT,ESR,and CRP in infection group accounted for 95.24％,80.95％ and 90.48％ respectively,in control group were 4.76％,14.29％,and 4.76％ respectively;the average concentrations of serum PCT,ESR,and CRP between two groups were compared respectively,differences were all significant(all P＜0.05).The sensitivity of PCT,ESR,CRP,and PCT + ESR + CRP in the diagnosis of intracranial infection after craniocerebral surgery in ICU patients were 95.24％,80.95％,90.47％,and 95.61 ％respectively;specificity were 95.23％,85.71％,95.23％,and 89.37％ respectively.Conclusion The combined detection of PCT,ESR,and CRP is helpful for the diagnosis of intracranial infection after craniocerebral surgery in ICU patients,it has important guiding significance for the rational use of antimicrobial agents in early stage.
