The roles of PPARs and PPARγ coactivator-1 alpha in mitochondrial cardiomyopathy
10.3760/cma.j.issn.2095-4255.2018.11.021
- VernacularTitle:PPARs及其共激活剂PGC-1α在线粒体心肌病中的作用
- Author:
Shuai JIANG
1
;
Jie HOU
;
Hong LIU
;
Dandan LI
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心克山病防治研究所
- Keywords:
Mitochondria;
Cardiomyopathy;
PPARs;
PPARγ coactivator-1 alpha
- From:
Chinese Journal of Endemiology
2018;37(11):943-946
- CountryChina
- Language:Chinese
-
Abstract:
In mitochondria,peroxisome proliferator activated receptor (PPARs) and PPARγ coactivator-1 alpha (PGC-1α) work together to regulate the energy metabolism.Mitochondrial cardiomyopathy is a disease characterized by myocardial damage and abnormal energy metabolic that results from abnormalities in mitochondria quantity,structure and function in cardiac myocytes.However,there is inadequate knowledge on the pathogenesis of mitochondrial cardiomyopathy.In this paper,we summarize the roles played by PPARs and PGC-1α in mitochondrial cardiomyopathy.We expect this paper will provide some new clues for further studies of mitochondrial cardiomyopathy.
