The mechanism of arsenicon keratinocytes: a review

VernacularTitle:砷对角质形成细胞作用机制的研究进展
Author: Zhongzhe LI ¹ ; Jinyin YAO ; Lin GAO
Author Information

1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心地氟病防治研究所
Keywords: Arsenic; Keratinocytes; Skin
From: Chinese Journal of Endemiology 2018;37(11):937-942
CountryChina
Language:Chinese
Abstract: Keratinocytes are the main constituent cells of the skin epidermis and the main target cells of arsenic act on the skin as well.Although it has been epidemiologically clarified that arsenic can cause palmoplantar hyperkeratosis and skin cancer,yet the mechanism is unclear and there's no ideal animal models so far.Currently,the studies of skin lesions induced by arsenic mainly focus on keratinocytes in vitro.In this paper,we summarize the related literatures and review the effects of arsenic on proliferation,differentiation,oxidative stress,DNA damage,apoptosis,epigenetic changes,and cancer stem cell activation of keratinocytes.We hope to deepen the understanding of skin lesions induced by arsenic and provide more basis and ideas for understanding the mechanism of endemic aRSenicosis.