Research progress on the relationship between osteoarthritis and life-related genes

VernacularTitle:骨关节炎与寿命相关基因关系的研究进展
Author: Yue WANG ¹ ; Wei LIAN ; Quanquan SONG ; Jun YU
Author Information

1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心大骨节病防治研究所
Keywords: Osteoarthritis; Longevity genes; Aging genes
From: Chinese Journal of Endemiology 2018;37(11):924-928
CountryChina
Language:Chinese
Abstract: Osteoarthritis (OA) is a chronic degenerative disease of active joints that is closely related to age.With the increase of age,chondrocytes gradually aging,synthetic and metabolic abilities gradually declined,cartilage matrix can not be effectively synthesized to maintain the amount of cartilage and cartilage structure,resulting in the occurrence of OA.In recent years,with the progress of OA pathogenesis in the field of genetics,the relationship between OA and the genes related to "aging" and "longevity" has gradually become the focus of research and made breakthrough progress.This article reviews current research on the relationship between "aging genes","longevity genes" and the pathogenesis of OA at home and abroad,and provides a reference for prevention and clinical treatment of OA.