The relationship between site polymorphism of GSTO1 gene rs4925 and As3MT gene rs11191439 and susceptibility to arsenic poisoning: a Meta-analysis
10.3760/cma.j.issn.2095-4255.2018.11.015
- VernacularTitle:GSTO1基因rs4925位点和As3MT基因rs11191439位点多态性与砷中毒易感性关系的Meta分析
- Author:
Lanrong LUO
1
;
Yanting ZHANG
;
Songbo FU
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心
- Keywords:
Arsenic poisoning;
Gene polymorphism;
Glutathione S-transferase omega1;
Arsenic (+3) methyltransferase
- From:
Chinese Journal of Endemiology
2018;37(11):917-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between site polymorphism of glutathione S-transferase omega1 (GSTO1) gene (rs4925),arsenic (+3) methyhransferase (As3MT) gene (rs11191439) and susceptibility to endemic arsenic poisoning.Methods All related studies in published papers up to March 1,2018 on association between site polymorphism of As3MT gene,GSTO1 gene and susceptibility to endemic arsenic poisoning were collected by searching PubMed,Embase,CNKI,Wanfang and VIP database.The data were screened according to the inclusion and exclusion criteria,and extracted,the quality of included studies was evaluated.The pooled odds ratios (OR) with 95％ confidence intervals (95％CI) were calculated using Review Manager 5.3 software.Publication bias and sensitivity analysis were also assessed.Results A total of 7 case-control studies involving 989 cases and 1 212 controls were included in the Meta-analysis.Individuals carrying at least one allele A at the rs4925 locus of the GSTO1 gene might increase the risk of susceptibility to arsenic poisoning compared with individuals carrying wild homozygous type [AA + CA vs CC,OR (95％CI) =1.37 (1.13,1.65),P ＜ 0.01].There was no statistically significant relationship between susceptibility to arsenic poisoning in individuals with at least one allele C at the rs1 1191439 locus of the As3MT gene compared with individuals carrying wild homozygous type [CC + TC vs TT,OR (95％CI) =1.12 (0.69,1.81),P ＞ 0.05].Conclusions GSTO1 gene rs4925 polymorphism is significantly associated with susceptibility to arsenic poisoning,and the A allele is a risk gene for susceptibility to arsenic poisoning.The As3MT gene rs1 1191439 locus polymorphism is not associated with susceptibility to arsenic poisoning.
