Effects of deoxynivalenol on articular cartilage injury
10.3760/cma.j.issn.2095-4255.2018.07.020
- VernacularTitle:脱氧雪腐镰刀菌烯醇对关节软骨损伤影响的研究进展
- Author:
Xiong LING
1
;
Haijuan REN
;
Yanhong CAO
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心大骨节病防治研究所
- Keywords:
Cartilage,articular;
Kaschin-Beck disease;
Deoxynivalenol
- From:
Chinese Journal of Endemiology
2018;37(7):599-602
- CountryChina
- Language:Chinese
-
Abstract:
Deoxynivalenol (DON) is one of mycotoxins produced by fungal pathogen of fusarium,which has strong cytotoxicity.The study of articular cartilage injury is focused on the study of Kaschin-Beck disease (KBD)pathogenesis.DON can inhibit the proliferation of chondrocytes,induce apoptosis,affect the cell-related metabolic enzymes and other ways to break the balance of chondrocytes and extracellular matrix,eventually leading to irreversible damage of articular cartilage.This article reviews the role of DON toxin in the cartilage injury.
