Updated progress in susceptibility genes and environmental response genes of Kaschin-Beck disease
10.3760/cma.j.issn.2095-4255.2018.03.019
- VernacularTitle:大骨节病易感基因及环境应答基因研究新进展
- Author:
Xiong LING
1
;
Haijuan REN
;
Tiantian LI
;
Yanhong CAO
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心大骨节病防治研究所
- Keywords:
Kaschin-Beck disease;
Pathogen;
Pathogenesis;
Control
- From:
Chinese Journal of Endemiology
2018;37(3):254-258
- CountryChina
- Language:Chinese
-
Abstract:
Kaschin-Beck disease is an endemic and deformed chronic osteochondropathy. Though the etiology is not well clear, the etiologic hypotheses have been mainly focused on bio-geochemical hypotheses, the hypotheses of mycotoxin poisoning under low selenium condition and the hypotheses of toxic organic compounds in drinking water. Prevention and control measures based on these hypotheses have shown remarkable achievements. Depending on the related research at home and abroad, this paper reviews the new developments of pathogen, pathogenesis and prevention on Kaschin-Beck disease in recent years.In terms of scientific research,new progresses have been made in the aspects of environmental factors associated with the pathogenesis of Kaschin-Beck disease, molecular biology, genomics, proteomics and environmental response genes. As for prevention and treatment, new progress has been made in such fields as supplement of selenium and treatment of traditional Chinese medicine.
