Association between nucleotide excision repair cross-complementing gene polymorphism and susceptibility to endemic arsenic poisoning
10.3760/cma.j.issn.2095-4255.2018.02.002
- VernacularTitle:核苷酸切除修复交叉互补基因多态性与地方性砷中毒易感性的关系
- Author:
Lanrong LUO
1
;
Yanhui GAO
;
Lijun ZHAO
;
Yuanyuan LI
;
Wei WEI
;
Hongqi FENG
;
Chuanying QIU
;
Qian HE
;
Songbo FU
;
Dianjun SUN
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心克山病防治研究所 卫计委病因流行病学重点实验室 黑龙江省普通高校病因流行病学重点实验室
- Keywords:
Arsenic poisoning;
Genotype;
Polymorphism,single nucleotide;
ERCC;
Disease susceptibility
- From:
Chinese Journal of Endemiology
2018;37(2):91-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between nucleotide excision repair cross-complementing (ERCC) gene polymorphisms [single nucleotide polymorphism (SNP) sites: rs11615, rs13181, rs238406, rs6498486, rs17655] and susceptibility to endemic arsenic poisoning. Methods The study recruited 848 subjects, including 348 cases and 500 controls, from populations exposed to high arsenic levels through drinking water in northwest China, and 3 - 5 ml venous blood was collected. The genotypes were determined using polymerase chain reaction and restriction fragment length polymorphism techniques(PCR-RFLP). Logistic regression analysis was used to assess the association of genotypes with endemic arsenic poisoning. Results The polymorphisms of rs11615 (ERCC1), rs238406 (ERCC2), rs6498486 (ERCC4) and rs17655 (ERCC5) and endemic arsenic poisoning were not related(P > 0.05). Participants who carried the CC genotype or at least one C allele for the ERCC2 rs13181 had an increased risk of endemic arsenic poisoning[OR(95%CI)=1.63(1.13,2.34),1.64(1.14,2.34)]compared with wild type homozygous individuals. Conculsions There is no positive correlation between the polymorphisms of ERCC1 rs11615, ERCC2 rs238406, ERCC4 rs6498486, ERCC5 rs17655 and endemic arsenic poisoning. ERCC2 rs13181 polymorphism increases the risk of endemic arsenic poisoning.
