Activin receptor-like kinase 1 and its roles in angiogenesis
10.3969/j.issn.1000-4718.2018.06.032
- VernacularTitle:活化素受体样激酶1及其在血管生成中的作用
- Author:
Bi-Lin LIN
1
;
Fang-Yun XU
;
Yong-Hong HUANG
Author Information
1. 南昌大学第二临床医学院
- Keywords:
Activin receptor-like kinase 1;
Angiogenesis;
Vascular development
- From:
Chinese Journal of Pathophysiology
2018;34(6):1147-1152
- CountryChina
- Language:Chinese
-
Abstract:
Activin receptor-like kinase (ALK) 1 is a transforming growth factor-β/bone morphogenetic pro-teins superfamily type Ⅰ receptor, predominantly expressed in active endothelial cells. ALK1 has been shown to play a piv-otal role in regulating angiogenesis, which is involved in vascular formation during embryonic and early postnatal develop-ment and angiogenesis-related diseases, such as cardiovascular disorders and tumor. Understanding the exact function of ALK1 in angiogenesis will provide theoretical basis for anti-angiogenic strategy of ALK1 inhibition. In the present study, we briefly recapitulate ALK1 signaling pathway and its role in blood vessel formation and pathological neovascularization.
