Relationship between phosphoglycerate kinase 1 and clinical features of prostate cancer and its role in prognosis
10.3969/j.issn.1000-4718.2018.06.030
- VernacularTitle:磷酸甘油酸激酶1和前列腺癌临床特征的相关性及在预后预测中的作用
- Author:
En-Shan PAN
1
;
Yu-Gang LI
;
Xiao-Guang ZHU
Author Information
1. 南方医科大学中医药学院
- Keywords:
Phosphoglycerate kinase 1;
Prostate cancer;
Tumor metastasis;
Prostate-specific antigen;
Progno-sis
- From:
Chinese Journal of Pathophysiology
2018;34(6):1138-1141,1146
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the expression and prognostic functions of phosphoglycerate kinase 1 ( PGK1) in prostate cancer. METHODS:The prostatic samples were collected from the patients with prostate cancer and benign pros-tatic hyperplasia (BPH) in TCM-Integrated Hospital of Southern Medical University from Jan 2013 to Dec 2013. The pro-tein expression of PGK1 in the prostate specimens was detected by immunohistochemical analysis and Western blot. Fur-thermore, the correlations of PGK1 expression with the clinicopathological features and prognosis of prostate cancer were al-so evaluate. RESULTS:The expression of PGK1 in the prostate specimens was significantly up-regulated compared with the BPH individuals. In addition, the expression of PGK1 was significantly correlated with the local infiltration, Gleason score, TNM grade, bone metastasis, and serum prostate-specific antigen (PSA) concentration. Finally, bone metastasis, serum PSA level and PGK1 expression were independent risk factors for prostate cancer illustrated by Cox analysis, and high expression of PGK1 was correlated with poor prognosis. CONCLUSION:PGK1 expression is an independent risk factor for prostate cancer, and it might act as a prognostic biomarker for prostate cancer.
