Antibacterial activity of TiO2 nanotube arrays on periodontal pathogens before and after loaded with minocycline hydrochloride
10.3969/j.issn.1000-4718.2018.05.021
- VernacularTitle:TiO2 纳米管阵列负载盐酸米诺环素前后抗牙周致病菌性能的研究
- Author:
Zhi-Ying ZHOU
1
;
Ting-Wei LI
;
Ye ZHANG
;
Yao-Dong CHENG
;
Chao WANG
;
Xiang-Ning LIU
;
Ren-Fa LAI
Author Information
1. 暨南大学附属第一医院口腔中心
- Keywords:
TiO2nanotube arrays;
Minocycline hydrochloride;
Periodontal pathogens
- From:
Chinese Journal of Pathophysiology
2018;34(5):909-912
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effects of titanium dioxide(TiO2)nanotube arrays on the early adhesion behavior of Porphyromonas gingivalis(Pg),Tannerella forsythia(Tf)and Actinobacillus actinomycetemcomitans(Aa)be-fore and after loaded with minocycline hydrochloride(MN).METHODS: TiO2nanotube arrays were prepared by ano-dization and loaded with MN.Titanium slices were divided into 3 groups according to different treatment methods: pure polishing titanium(Ti)group,TiO2nanotube titanium(TiO2)group, and MN(120 μg)TiO2nanotube titanium(MN TiO2)group.The antibacterial properties of the titanium tablets were evaluated by the bacteriostasis test.RESULTS:The Ti had no antibacterial activity.The antibacterial activity of TiO 2to Aa,Pg and Tf was poor,with only about 20%of anti-bacterial rate after 4 h.After loaded with MN,its antibacterial activity was enhanced,and the antibacterial rate was up to 77%after 4 h.CONCLUSION: No antibacterial activity in the Ti group was observed.If TiO2nanotube arrays were formed on the surface and MN was loaded,the antibacterial activity on periodontal pathogens was stronger.
