Advance of exosomes in ischemic stroke
10.3969/j.issn.1000-4718.2018.03.032
- VernacularTitle:外泌体在缺血性脑卒中的研究进展
- Author:
Yi CHAI
1
;
Chen-Xing JI
;
Xin-Gen ZHU
;
Zi-Yun GAO
Author Information
1. 上饶市人民医院神经外科
- Keywords:
Exosome;
Stroke;
Neuroprotection;
Neurotherapy
- From:
Chinese Journal of Pathophysiology
2018;34(3):572-576
- CountryChina
- Language:Chinese
-
Abstract:
Stroke is one of the major causes of death and disability in China and even worldwide.At present, treatment of stroke has been traditionally focused on reducing death of ischemic cells.However,clinical trials have shown that none of neuroprotective drugs tested achieve clinical benefit after acute stroke.Exosomes are 30~100 nm extracellular vesicles derived from cells with cell membrane structure.Many studies suggest exosomes play essential roles in intercellular communication by transferring their cargo between source and target cells in brain.Emerging data show that exsomes also make a contribution to brain recovery via regulating highly interactive process pathway after stroke.Here,we review these advances and highlight the potential therapeutic functions of exosomes in brain remodeling after stroke.
