Methods and Clinical Efficacy of Dosimetry-Based Treatment in Radioiodine Therapy of Thyroid Cancer.
10.11106/jkta.2013.6.1.43
- Author:
Jin Chul PAENG
1
;
June Key CHUNG
Author Information
1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea. jkchung@snu.ac.kr
- Publication Type:Review
- Keywords:
Thyroid cancer;
Radioiodine;
Dosimetry;
Fixed dose
- MeSH:
Humans;
Prognosis;
Radiometry;
Thyroid Gland;
Thyroid Neoplasms
- From:Journal of Korean Thyroid Association
2013;6(1):43-48
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Radioiodine (RI) therapy is one of the key factors for the good prognosis of differentiated thyroid cancers. Currently, most of RI treatments are performed with predetermined fixed dose of RI, whereas strict dose adjustment is made in chemotherapy or external radiotherapy for cancer treatment. Although fixed dose methods have been practically effective in RI therapy hitherto, dose determination with individual radiation dosimetry is theoretically superior to use of empirical fixed dose, for maximization of treatment effect and minimization of adverse events. The theoretical superiority of dosimetry-based dose determination is not yet directly supported by clinical data of real world; however, indirect results support the use of dosimetry-based dose determination in several specific patient groups. In this review, the basis of dosimetry is briefly discussed with regard to necessity and practical methods. Additionally, the efficacy of dosimetry is also discussed through the data of clinical studies so far.
