Advances of phosphatase of regenerating liver-3 in hematological malignancies
10.3969/j.issn.1000-4718.2018.02.030
- VernacularTitle:肝再生磷酸酶3在恶性血液病中的研究进展
- Author:
Feng-Qi LIU
1
;
Li-Mei XU
;
Juan LI
;
Hai-He WANG
;
Xiu-Zhen TONG
Author Information
1. 中山大学附属第一医院血液科
- Keywords:
Phosphatase of regenerating liver-3;
Acute myeloid leukemia;
Multiple myeloma;
Chronic mye-loid leukemia
- From:
Chinese Journal of Pathophysiology
2018;34(2):375-379
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,accumulating evidence shows that phosphatase of regenerating liver-3(PRL-3)is closely implicated in tumor progression,especially in the stages of invasion and metastasis of various solid tumors, inclu-ding colorectal cancer,gastric cancer and breast cancer.However,the study of PRL-3 in hematological malignancies is rel-atively lagged,but there are some advances in leukemia and myeloma,in which PRL-3 up-regulation is tightly associated with poor prognosis,while the underlying mechanism of signal transduction is gradually explored.In this review,we sum-marized the recent advances of PRL-3 in hematological malignancies such as acute myeloid leukemia,multiple myeloma and chronic myeloid leukemia,as well as the molecular mechanism of PRL-3 in pathogenesis.
