Roles of β-cell dedifferentiation in β-cell dysfunction
10.3969/j.issn.1000-4718.2018.02.029
- VernacularTitle:胰岛β细胞退分化在β细胞功能衰竭中的作用
- Author:
Jun-Nan LI
1
;
Yang YU
;
Hong-Wei DU
Author Information
1. 吉林大学基础医学院药理学系
- Keywords:
Type 2 diabetes;
β-cell dedifferentiation;
β-cell dysfunction
- From:
Chinese Journal of Pathophysiology
2018;34(2):371-374
- CountryChina
- Language:Chinese
-
Abstract:
β-cells may turn into other pancreatic islet cells through dedifferentiation.The dedifferentiation cells lose the ability of insulin secretion.Islet β-cell dedifferentiation is the important cause of β-cell dysfunction, which then leads to the occurrence of type 2 diabetes.Rescent research shows that many transcription factors play an important role in β-cell dedifferentiation,including forkhead box protein O1,NKX2.2,NKX6.1,MAFA and MAFB.In this paper, the influence factors of β-cell dedifferentiation and its mechanism were reviewed briefly.The discovery of β-cell dedifferen-tiation provides new thoughts and targets for prevention and treatment of type 2 diabetes.