Effect of Fufang Zhenzhu Tiaozhi capsule on serum lipids and inflamma-tory factors in rabbit abdominal aortic restenosis model
10.3969/j.issn.1000-4718.2018.02.013
- VernacularTitle:复方贞术调脂胶囊对兔腹主动脉再狭窄模型血脂及炎症因子的影响
- Author:
Ren-Dan ZHANG
1
;
Tu-Di LI
;
Jia-Wei WANG
;
Hui-Jian DENG
;
Zhi-Huan ZENG
Author Information
1. 广东药科大学附属第一医院
- Keywords:
Fufang Zhenzhu Tiaozhi capsule;
Restenosis;
Blood lipids;
Inflammatory factors;
NF-κB
- From:
Chinese Journal of Pathophysiology
2018;34(2):270-275
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect of Fufang Zhenzhu Tiaozhi capsule(FTZ)on serum lipids and in-flammatory factors in rabbits with abdorminal aortic restenosis after balloon angioplasty.METHODS: New Zealand white rabbits(n=30)were divided into 5 groups.Except blank control group,the rabbits in other groups were used to establish abdominal aortic endothelium exfoliative vascular stenosis model.After 4 weeks of high-fat diet feeding,the animals in rest-enosis model group and drug treatment groups underwent percutaneous balloon dilatation in the stenosis.The angiographic stenosis was analyzed by a two-dimensional quantitative coronary angiography workstation with a digital subtraction X -ray machine.Blood samples were taken during angiography and the profiles of serum lipids and cytokines were measured.The expression of nuclear factor-κB(NF-κB)in the blood vessels was determined by immunohistochemistry.RESULTS:An-giography confirmed that the rates of area stenosis and diameter stenosis were significantly decreased in treatment groups compared with restenosis model group(P<0.01).Compared with restenosis model group,the serum lipid profiles and cy-tokine concentrations in drug treatment groups were significantly decreased(P<0.05).Immunohistochemistry showed the expression of NF-κB in restenosis model group was significantly higher than that in blank control group and drug treatment groups(P<0.05).CONCLUSION: FTZ significantly reduces the blood lipids and inflammatory factors in abdominal aortic restenosis model,and the anti-inflammatory effect may be related to the regulation of NF-κB pathway to inhibit the production of various inflammatory factors.
