Clinicopathologic Characteristics of Papillary Microcarcinoma in the Elderly.
10.11106/jkta.2013.6.1.69
- Author:
Won Jin KIM
1
;
Min Jung BAE
;
Yang Seon YI
;
Yun Kyung JEON
;
Sang Soo KIM
;
Bo Hyun KIM
;
In Joo KIM
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea. injkim@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Papillary thyroid microcarcinoma;
Age;
Clinicopathologic features
- MeSH:
Aged;
Carcinoma;
Carcinoma, Papillary;
Female;
Humans;
Lymph Nodes;
Male;
Neoplasm Metastasis;
Prevalence;
Thyroid Gland;
Thyroid Neoplasms;
Thyroidectomy
- From:Journal of Korean Thyroid Association
2013;6(1):69-74
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Older patients show more aggressive features in papillary thyroid carcinoma (PTC). However, data about clinicopathologic features of older patients in papillary thyroid microcarcinoma (PTMC) are limited. Presently, we investigated the difference of clinicopathologic features in PTMC according to age. MATERIALS AND METHODS: A total of 820 PTMC patients (82 males, 10%; 738 females, 90%) who underwent total thyroidectomy at Pusan National University Hospital were enrolled. The patients were divided into three age groups: group 1 (44 years or younger, n=230), group 2 (45-64 years, n=513), and group 3 (65 years or older, n=77). RESULTS: Extrathyroidal extension was 33% in group 1, 32.2% in group 2, and 31.2% in group 3 (p=0.948). There was no significant difference of lymph node metastasis between the groups: N0 (59.1% vs. 67.8% vs. 70.1%), N1a (37.4% vs. 28.8% vs. 26%), and N1b (3.5% vs. 3.3% vs. 3.9%) (p=0.159). Of the 820 patients, 526 (64.1%) were diagnosed as early stage (stage I, II) PTMC and 294 (35.9%) were diagnosed as advanced stage (stage III, IV) PTMC. The proportion of patients with each stage was significantly different between the groups (p<0.001). However, there was no significantly difference in the stage over 45 years old. Of the 820 patients, 517 were evaluated BRAF(V600E) mutation. There was no difference in prevalence between each group. CONCLUSION: There was no statistically significant difference of clinicopathologic features between the groups, indicating that old age itself was not associated with unfavorable clinicopathologic features in PTMC.
