Effect of SerpinE2 on metabolism of extracellular matrix
10.3969/j.issn.1000-4718.2018.01.030
- VernacularTitle:SerpinE2在细胞外基质代谢中作用的研究进展
- Author:
Ying FENG
1
;
Xiao LIU
;
Xiao-Qiang E
;
Xue-Lian LI
Author Information
1. 哈尔滨医科大学 药学院药理教研室
- Keywords:
Serine peptidase inhibitor clade E member 2;
Extracellular matrix;
Tumour;
Fibrosis
- From:
Chinese Journal of Pathophysiology
2018;34(1):173-177
- CountryChina
- Language:Chinese
-
Abstract:
Serpin peptidase inhibitor clade E member 2(SerpinE2),a member of serine peptidase inhibitor super family,regulates multiple serine proteases.Extracellular matrix(ECM)plays an important role in stem cell differen-tiation,signal transduction,tumor metastasis,osteoarthritis physiological and pathological processes and so on.SerpinE2 regulates the protein of extracellular matrix by serine protease system and matrix metalloproteinase(MMP)system.In this paper,we elaborate the effect of SerpinE2 on metabolism of extracellular matrix,and it will provide new ideas to find new therapeutic targets.
