Protective Effects of ACEI Drugs on Radiation-induced Lung Injury:A Meta-analysis

VernacularTitle:ACEI对放射性肺损伤保护作用的Meta分析
Author: Chunyang ZHAO ¹ ; Lichao YANG ; Jiayi CAI ; Mingyan JIANG
Author Information

1. 中国医科大学附属第一医院药学部
Keywords: ACEI; Lung injury,radiation-induced; Pneumonia,radiation; Meta-analysis
From: Herald of Medicine 2018;37(11):1404-1408
CountryChina
Language:Chinese
Abstract: Objective To evaluate the protective effect of ACEI drugs on radiation pneumonitis,and to compare ACEI with ARB,statin, steroid, and NSAID on the treatment of radiation induced lung injury through the network Meta-analysis. Methods A computer-based online search of PubMed, EMbase, Cochrane Library, as well as CNKI, CBM, VIP, Wanfang database was conduce. The NOS score was used to evaluate the quality of studies,and the results were analyzed by stata14. 0 software. Results ACEI drugs showed desired effect on the treatment of radiation pneumonia,which can effectively reduce the incidence of radiation-induced lung injury,but can not prolong the survival time of the patients.The protective effects of statins and non-steroid anti-inflammatory drugs are second only to those of ACEI.Meta-analysis results were proved to be stable and credible by the sensitive-analysis.The therapeutic effect of ACEI on radiation induced lung injury is not affected by sex and age of patients. Conclusion ACEI drugs have an optimum protective effect on radiation induced lung injury.