Dissolution Determination of Ambroxol Hydrochloride Orally Disinegreting Tablets
10.3870/j.issn.1004-0781.2018.11.026
- VernacularTitle:盐酸氨溴索口腔崩解片的溶出度测定
- Author:
Tao LUO
1
;
Hao ZHANG
;
Jinzhe CHEN
Author Information
1. 武汉大学中南医院
- Keywords:
Ambroxol hydrochloride orally disinegreting tablets;
Dissolution;
Spectrophotometry,UV
- From:
Herald of Medicine
2018;37(11):1401-1403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method for the dissolution determination of ambroxol hydrochloride orally disinegreting tablets. Methods The UV spectrophotometry was used. The detecting wavelength was at 244 nm. The liquid of dissolution was hydrochloride(0.1 mol·L -1). Rotational speed was 50 r·min-1. Results The linearity range was 3.16-28.44 μg·mL-1.The regression equation was Y＝0.024 2X+0.018 3(r＝0.999 3).The RSD of repeatable test was 0.28%.The average recovery of methodology was 100.4% and RSD was 0.77%. Conclusion The method is simple and reliable, and can be used for the dissolution determination of ambroxol hydrochloride orally disinegreting tablets.
