Fingerprint Analysis of Volatile Components of Golden Throat Lozenges by GC-MS
10.3870/j.issn.1004-0781.2018.11.022
- VernacularTitle:金嗓子喉片挥发性成分气相色谱-质谱指纹图谱分析
- Author:
Rongrong XU
1
;
Hua LIN
;
Qingfang QIN
;
Dongmei HUANG
;
Yuan WU
Author Information
1. 广西壮族自治区柳州市食品药品检验所
- Keywords:
Golden throat lozenges;
Fingerprint;
Volatile components;
Gas chromatography-mass spectrometry
- From:
Herald of Medicine
2018;37(11):1386-1388
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish fingerprint of volatile components in golden throat lozenges by GC-MS. Methods Volatile components from 10 batches of golden throat lozenges were extracted by steam distillation method and analyzed by GC-MS with n-tetradecane as internal standard. Fingerprint peak detection and similarity evaluation were applied to the total ion chromatogram(TIC)of GC-MS by "Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine (Version 2004)" ,fingerprint peak was identified by mass spectrometry. Results A GC-MS fingerprint was established based on 10 common peaks as characteristic fingerprint information.The similarity of fingerprint peaks from the 10 batches of samples were more than 0.998.Ten fingerprint peaks were determined by mass spectrometry, all of which were composed of monoterpenes and monoterpenes containing oxygen, the highest content of which was L-menthol containing oxygen monoterpenes, accounting for 83.17% of the total. Conclusion The fingerprint established by gas chromatography-mass spectrometry can completely reflect the volatile components of golden throat lozenges tablets, with strong characteristics and specificity, and can be used as an effective method for the quality control of volatile components inf golden throat lozenges.
