Preparation and Stability of Loratadine Nanoparticle Suspension

VernacularTitle:氯雷他定纳米混悬剂的制备与稳定性考察
Author: Miao SHI ¹ ; Hong ZHANG ; Jian LYU ; Ruidan BAI ; Cuiyuan HUANG
Author Information

1. 武汉大学人民医院药学部
Keywords: Loratadine; Nanoparticle suspension; Stability
From: Herald of Medicine 2018;37(11):1381-1385
CountryChina
Language:Chinese
Abstract: Objective To prepare loratadine nanoparticle suspension and investigate the stability of it. Methods Loratadine nanoparticle suspension was prepared by anti-tumor agent precipitation method,the nanosuspension was characterized by particle size analyzer and transmission electron microscopy, the optimal prescription was screened, and the stability of nanosuspension was investigated by HPLC. Results The optimal prescription stablizer was SDS and organic phase was ethanol. The drug loading radio was 1:2 and the proportion of organic phase to water was 5:10 and the time of high shear was 5 min. Loratadine suspension was pale blue with a uniform emulsion.The nanoparticles were spherical,with an average particle size of 112.8 nm,the PDI of 0.095 and the Zeta potential of -38.6 mV.The suspension had the best physical and chemical stability at room temperature. Conclusion The preparation method of loratadine suspension with good stability is simple, and it’s expected to become the new nano-drug delivery system of loratadine.