Median Effective Dose ( ED50) of Ropivacaine in Ultrasound-guided Transversus Abdominis Plane Block for Analgesia in Patients Undergoing Appendectomy
10.3870/j.issn.1004-0781.2018.11.011
- VernacularTitle:罗哌卡因用于阑尾切除术患者超声引导下腹横肌平面阻滞的半数有效镇痛剂量
- Author:
Yafei CHEN
1
;
Miao CHEN
;
Yuhua ZHAO
;
Xueping HAN
Author Information
1. 郑州大学第一附属医院麻醉科
- Keywords:
Ropivacaine;
Transversus abdominis plane block;
Median effective dose;
Appendectomy
- From:
Herald of Medicine
2018;37(11):1345-1347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the median effective anesthetic dose of ropivacaine in ultrasound-guided transversus abdominis plane ( TAP ) block for analgesia in patients undergoing appendectomy. Methods Twenty-eight cases of appendectomy under general anesthesia were analyzed.After standardized general anaesthesia,a bilateral ultrasound-guided TAP block was performed on patients undergoing appendectomy using ropivacaine. Sequential method was applied. The initial dose of ropivacaine in first patient was 1.6 mg·kg-1,the dose adjustment interval was 0.2 mg·kg-1.Numerical Rating Scale was used to estimate the level of pain postoperatively. If NRS≤3, dosage of ropivacaine was decreased by 0. 2 mg·kg-1. The transversus abdominis plane block analgesia duration and incidences of postoperative adverse reactions were analyzed. Results Median effective dose (ED50) of ropivacaine in ultrasound-guided transversus abdominis plane block was 2.73 mg·kg-1.95%CI (1.94, 3.84) mg·kg-1. Conclusion The determination of ED50of ropivacaine in ultrasound-guided transversus abdominis plane block improved the anesthesia efficacy and safety.
