Efficacy and Safety of Citric Acid Tandospirone Citrate in the Treatment of Generalized Anxiety Disorder:A Systematic Review
10.3870/j.issn.1004-0781.2018.03.022
- VernacularTitle:枸橼酸坦度螺酮治疗广泛性焦虑症有效性和安全性的系统评价
- Author:
Ya ZHOU
1
;
Xuefei HUANG
;
Kun CHEN
;
Yun YE
Author Information
1. 西南医科大学药学院临床药学教研室
- Keywords:
Tandospirone citrate;
Generalized anxiety disorder;
Effectiveness;
Safety;
Meta-analysis
- From:
Herald of Medicine
2018;37(3):368-373
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the efficacy and safety of tandospirone in the treatment of generalized anx-iety disorder(GAD) and to provide evidence-based references for clinic. Methods Databases include PubMed,Embase,The Co-chrane Library,CBM,CNKI,VIP and Wanfang Data were electronically searched from the inception to November 2016,to collect randomized controlled trials(RCTs)about the tandospirone citrate in the treatment of generalized anxiety disorder.Meta-analysis was performed by RevMan5.3 software after data extraction and quality evaluation. Results A total of 5 RCTs involving 500 patients were included.The results of Meta-analysis showed no significant differences in the Hamilton Anxiety Scale(HAMA) score between experimental group and control group[MD=0.47,95%CI(-0.51,1.45),P=0.34];and there was no significant differences of total effective rate between experimental group and control group[OR=1.03,95%CI(0.64,1.67),P=0.90].The incidence of adverse reactions in experimental group was significantly lower than that of control group,the difference was statistically significant[OR=0. 65,95%CI(0.44,0.95),P=0.03]. Conclusion Tandospirone citrate,as a new type of non-BZDs of antianxiety drug,shows exact clinical curative effect in the treatment of generalized anxiety disorder with mild adverse reaction and good safety.
