Pretreatment Conditions in the Detection of Selenium from Hugan Tablets by Central Composite Design-Response Surface Methodology
10.3870/j.issn.1004-0781.2018.03.019
- VernacularTitle:星点设计-效应面法优选护肝片中硒测定的前处理条件
- Author:
Qi LI
1
;
Hehuan PEI
Author Information
1. 广西壮族自治区桂林食品药品检验所
- Keywords:
Hugan tablets;
Selenium;
Central composite design;
Response surface methodology;
Pretreatment condition
- From:
Herald of Medicine
2018;37(3):351-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the pretreatment conditions in the detection of selenium from hugan tablets. Methods The main influential factors of pretreatment conditions included concentration of hydrochloric acid,time in water bath and concentration of potassium ferricyanide solution.The extraction effect was evaluated with the content of selenium.Pretreatment conditions were optimized by central composite design-response surface methodology. Results The best pretreatment conditions was 6 mol·L-1hydrochloric acid,30 minutes of bathing in water bath,20%potassium ferricyanide solution. Conclusion The central composite design-response surface methodology is highly predictive,reasonable and feasible.
