Preparation Strategy for Improving the Bioavailability of Resveratrol
10.3870/j.issn.1004-0781.2018.03.015
- VernacularTitle:提高白藜芦醇生物利用度的制剂策略
- Author:
Dan LIU
1
;
Lihong YU
;
Lei LI
Author Information
1. 解放军第210医院药剂科
- Keywords:
Resveratrol;
Bioavailability;
Targeted preparation,Sustained-and controlled-released preparation
- From:
Herald of Medicine
2018;37(3):333-337
- CountryChina
- Language:Chinese
-
Abstract:
Resveratrol,a naturally occurring polyphenol and phytoalexin,has received significantly attention in recent years due to its vast therapeutic effects including anticancer,antioxidant and anti-inflammatory effects,etc.However,poor pharma-cokinetic properties such as low aqueous solubility,low photo-stability and extensive first pass metabolism result in poor bioavail-ability,which hindering its immense potential.A number of theoretical solutions have been developed to improve the bioavailabili-ty of resveratrol.This review enumerates the physicochemical and pharmacokinetic properties that affect resveratrol bioavailability, describes formulations tested for resveratrol administration and identifies future opportunities for resveratrol delivery.
