Effects of Different Dose 60Co Irradiation on Content of Isoimperatorin in Fengshi Bitong Capsule
10.3870/j.issn.1004-0781.2018.02.018
- VernacularTitle:不同剂量60Co辐照对 风湿痹痛胶囊中异欧前胡素含量的影响
- Author:
Mutu HUANG
1
;
Xinmin XIE
;
Mei ZHANG
;
Lanlan LIN
;
Liping HAN
Author Information
1. 广州军区广州总医院药学部
- Keywords:
Fengshi Bitong capsule;
60Co irradiation;
Isoimperatorin
- From:
Herald of Medicine
2018;37(2):217-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method for isoimperatorin in Fengshi Bitong capsule and to study the effects of different doses of 60Co irradiation on the content of isoimperatorin. Methods The Agilent C18 column(4.6 mm×150 mm, 5μm) was used with the mobile phase consisted of acetonitrile -water (41:59) ;The flow rate was 1.0 mL?min-1 ,the detection wavelength was at 310 nm,and the column temperature was at 30 ℃ . Results Isoimperatorin showed a good linear relationship within a range of 3.66896-183.448 μg? mL-1( r = 1.0000).The average rate of recovery was 96.42％, RSD = 2.61％.The content of isoimperatorin in Fengshi Bitong capsule did not change significantly when irradiated by 2, 5 and 10 kGy of 60Co. Conclusion The established methods can be used for isoimperatorin determination in Fengshi Bitong capsule with high specificity,accuration and feasibility.The influence was not significant when the irradiation dose was less than 10 kGy.
