Preparation of Scutellarin Liposomes and Its Pharmacokinetics in Rats
10.3870/j.issn.1004-0781.2018.02.017
- VernacularTitle:灯盏乙素脂质体的制备及其在大鼠体内药动学
- Author:
Jianming LIU
1
;
Zijin XU
;
Yuxiu YANG
;
Fang WANG
;
Fen LIU
Author Information
1. 江西医学高等专科学校
- Keywords:
Scutellarin;
Liposomes;
Encapsulation efficiency;
Carbopol;
Pharmacokinetics
- From:
Herald of Medicine
2018;37(2):212-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare scutellarin liposomes and to investigate the pharmacokinetics in rats. Methods The liposomes of scutellarin coated with carbopol were prepared with the film dispersion method.Minicolumn centrifugation method was applied to measure the encapsulation efficiency (EE) before and after coating. SD rats were randomly divided into three groups, which were given intragastric administration of scutellarin suspension, scutellarin liposomes, and carbopol-coated scutellarin liposomes, respectively. And then the pharmacokinetic parameters were compared. Results Carbopol-coated scutellarin liposomes after intragastric administration in rats showed pharmacokinetic characteristics of two-compartment model. The main pharmacokinetic parameters of scutellarin suspension,scutellarin liposomes,and carbopol-coated scutellarin liposomes were as follows:AUC0-∞(50.03±13.45) μg?h?mL-1 ,(78.99±20.28) μg?h?mL-1 ,and (107.97±27.26) μg?h?mL-1 , respectively. Conclusion After coated liposomes, the oral bioavailability of scutellarin 1iposomes can be significantly improved,and the maximum drug concentration also increased.
