Correlation Between Cutaneous Adverse Reactions Caused by Aromatic Antiepileptic Drugs and Human Leukocyte Antigen Gene Polymorphism
10.3870/j.issn.1004-0781.2018.02.016
- VernacularTitle:芳香族抗癫药物导致皮肤不良反应 与人类白细胞抗原基因多态性的相关性
- Author:
Jiping HUO
1
;
Jingchen TIAN
;
Zhigang ZHAO
;
Shenghui MEI
;
Xingang LI
;
Kefu YU
Author Information
1. 首都医科大学附属北京天坛医院药学部
- Keywords:
Antiepileptic drugs,aromatic;
Adverse drug reactions;
cutaneous;
Human leukocyte antigen;
Gene polymorphism
- From:
Herald of Medicine
2018;37(2):206-211
- CountryChina
- Language:Chinese
-
Abstract:
Aromatic antiepileptic drugs such as carbamazepine are the first-line treatment for epilepsy. The adverse reactions have greatly limited their clinical application. The occurrence rate of severe skin adverse reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is low,but they are often fatal.Human leukocyte antigen (HLA) gene polymorphisms are reported to be related with skin adverse reactions caused by aromatic antiepileptic drugs,but the exact mechanism is unclear.This article will perform a review about the correlation between skin adverse reactions caused by aromatic antiepileptic drugs and HLA gene polymorphisms published in recent years,in order to provide theoretical basis for further study of HLA susceptibility genes in Chinese Han population,and provide a reference for achieving individualized treatment of epilepsy.
