Effect of Effective Fraction from Radix Vitis Davidii Foex. on Fracture Healing
10.3870/j.issn.1004-0781.2018.02.004
- VernacularTitle:独正杆有效部位促骨折愈合作用
- Author:
Xianshun XU
1
;
Huabin HUANG
;
Zhongxian WAN
;
Yuancheng LUO
;
Fei WU
;
Yuancui XU
Author Information
1. 湖北省恩施土家族苗族自治州中心医院中医部药剂科
- Keywords:
Radix Vitis Davidii Foex.;
Effective fraction;
Fracture healing;
Yunnan Baiyao
- From:
Herald of Medicine
2018;37(2):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of effective fractions from Radix Vitis Davidii Foex. on fracture healing. Methods SD rats were randomly divided into model control group,Yunnan Baiyao group,and effective fraction group (n= 36 each group). Fracture models were established. Rats in the Yunnan Baiyao group and effective fraction group were given 3.0 g?kg-1?d-1 of Yunnan Baiyao and effective fraction from Radix Vitis Davidii Foex.,respectively,and rats in the model control group was treated with the same volume of pure water. Alkaline phosphatase and Ca concentration in serum were determined.For radius fracture structure,digital radiography and RT-PCR detection of VEGF mRNA expression were performed. Results The peak concentration of the alkaline phosphatase and Ca concentration in serum were significantly higher in the effective fraction group than in the Yunnan Baiyao group,and peak value appeared earlier,fracture healing score was higher, fracture line disappeared earlier,and VEGF mRNA expression was significantly higher in three weeks after the fracture (all P<0. 01) . Conclusion The effect of the effective fraction from RadixVitis Davidii Foex.on the fracture healing is strong.
