Research Progress in Clopidogrel Resistance
10.3870/j.issn.1004-0781.2018.02.001
- VernacularTitle:氯吡格雷抵抗研究进展
- Author:
Menglu FU
1
;
Ruolan DONG
;
Ling TU
;
Xizhen XU
Author Information
1. 华中科技大学同济医学院附属同济医院综合医疗科
- Keywords:
Clopidogrel resistance;
Anti-platelet drugs
- From:
Herald of Medicine
2018;37(2):139-145
- CountryChina
- Language:Chinese
-
Abstract:
Clopidogrel is one of the anti-platelet drugs, which is widely used in the world.It plays an important role in the treatment of patients with acute coronary syndrome and those undergoing percutaneous coronary intervention.Clopidogrel is effective in inhibiting the activity of platelets, decreasing the incidence of thrombosis in the stent, and then reducing the risk of adverse cardiovascular events in affected individuals. However, some patients still have coronary thrombosis after taking clopidogrel.This phenomenon is known as clopidogrel resistance or clopidogrel non-response or low response. Identification of clopidogrel resistance is of great significance in preventing the occurrence of adverse cardiovascular events.This paper provides guidance for the clinical treatment of clopidogrel resistance by discussing the definition, mechanisms and laboratory evaluation of clopidogrel resistance.
