Correlation between the Human Telomerase Gene (hTERC) and the Generation and Progression of Cervical Cancer
10.11969/j.issn.1673-548X.2018.06.038
- VernacularTitle:hTERC基因与宫颈癌发生、发展相关性
- Author:
Yanxin NIU
1
;
Nan WANG
Author Information
1. 321000,金华市人民医院妇产科
- Keywords:
Human telomerase gene;
Cervical cancer;
Cervical lesions;
Correlation
- From:
Journal of Medical Research
2018;47(6):164-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the human telomerase gene (hTERC) and the generation and progression of cervical cancer.Methods A total of 173 patients with abnormal results of cervical biopsy by colposcopy were selected,meanwhile the 40 normal cases were selected as control group.The expression of hTERC gene was detected by fluorescence in situ hybridization (FISH),and the relationship between the HPV infection and the positive rate of hTERC was analyzed.Results The positive rate of hTERC in the control group was 7.50％,which was respectively 15.79％,46.15％,68.63％,and 91.11％ in the CIN Ⅰ group,CIN Ⅱ group,CIN Ⅲ group,and cervical cancer group.The positive rate of the hTERC was significantly increased during the progression of cervical exfoliative cell lesions (P ＜ 0.05).The precancerous lesion and cancer rate in patients with high-risk HPV infection and positive hTERC was 100％,significantly higher than that of patients with high-risk HPV infection as well as positive hTERC and also non high-risk HPV infected patients (P ＜ 0.05).Conclusion hTERC gene amplification is involved in the development of cervical cancer,and increase with cervical lesions rising,and the positive expression of hTERC gene is valuable to the early diagnosis of cervical cancer.
