Expression and Clinical Significance of USP39 in Colon Cancer
10.11969/j.issn.1673-548X.2018.04.039
- VernacularTitle:泛素化特异性蛋白酶39在结肠癌组织中的表达及临床意义
- Author:
Lianhua ZHANG
1
;
Guoying TANG
Author Information
1. 405400,重庆市开州区人民医院肿瘤科
- Keywords:
USP39;
Colon cancer;
Survival;
Prognosis
- From:
Journal of Medical Research
2018;47(4):160-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of USP39 in tissues of colon cancer (CRC),investigate the association of the expression levels of USP39 and clinicopathological features of CRC patients,and analyze the relevance of USP39 and survival and prognosis of CRC patients.Methods Expressions of USP39 were analyzed by immunohistochemistry in 77 CRC patients.Spearman's rank test,K-M survival curves,and Cox proportional hazards risk were conducted to analyze the clinical relevance of USP39 in CRC.Results Immunohistochemistry revealed that the positive rate of USP39 was upregulated in CRC tissues compare with adjacent tissues Spearman rank correlation showed that positive USP39 expression was significantly associated with TNM stage,lymph node status and venous invasion of CRC patients.Kaplan-Meier curves showed that positive USP39 expression was inversely correlated with 5 years overall and progression-free survival time of CRC patients.Cox proportional hazards risk analysis revealed that USP39 was an independent prognostic factor for CRC.Conclusion USP39 expression is upregulated in tissues of CRC,and USP39 is a potential survival and prognosis biomarker in CRC.
