Macrophage Migration Inhibitory Factor Promoter Polymorphisms (-173G/C) : Relationship with Coronary Atherosclerotic Disease Subjecrs

VernacularTitle:MIF基因启动子区-173多态性与冠心病相关性研究
Author: Lu QIAN ¹ ; Ripeng YIN
Author Information

1. 325000,温州医科大学附属第二医院
Keywords: Macrophage migration inhibitory factor; Promoter; Gene polymorphisms; Coronary atheroselerotic disease
From: Journal of Medical Research 2018;47(4):32-35
CountryChina
Language:Chinese
Abstract: Objective We analyzed the relationship of-173G/C MIF polymorphisms with soluble MIF in Coronary Atherosclerotic Disease (CAD) patients.Methods A total of 347 patients were selected,of which 229 normal-coronary and 118 Coronary artery disease subjects.Genotyping of-173G/C polymorphisms were performed by PCR and DNA sequencing.Serum MIF levels were measured using an ELISA kit.Patients were classified by coronary angiogram.Results (1) The frequency of the C genotype was higher in CAD patients than in the control.(2) Serum MIF levels was higher in 173C subjects than in 173G subjects.In addition,we found an increase in serum MIF levels in carriers of the (C/C) genotypes the-173 MIF polymorphisms.Conclusion These data suggest that MIF-173G/C polymorphism may be related to the development of CAD in a Chinese population.