Research of the Curative Effect about New Compound Dressing in Promoting Epithelial Repaired of Ⅱ ° Burned Wound in Rats
10.11969/j.issn.1673-548X.2018.03.027
- VernacularTitle:新型复合敷料促进大鼠Ⅱ°烧伤创面再上皮化的疗效研究
- Author:
Baichuan LI
1
,
2
;
Songshen CAO
;
Hongli LI
Author Information
1. 400038 重庆,第三军医大学组织学与胚胎学教研室
2. 350003 福州,中国人民解放军61716部队门诊部
- Keywords:
Compound dressing;
Calcium antagonist;
Epithelial;
Wound healing
- From:
Journal of Medical Research
2018;47(3):105-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a new compound dressing which can both anti-inflammatory and promote skin quickly epithelial repairing,and then study the curative effect.Methods First,the wound injury model was established.The samples were randomly divided into normal,injury and treatment group which were treated with dressing after injury.Next,the wound skin tissues were taken in injured after 1days,3days,7days and 14days.Then,each area of the wound was measured and the wound healing rate were calculated.Total Ca2 + concentration and the difference of active oxygen in skin tissue between each groups were compared.The secretion of TNF-α,IL -1 and IL-6 were detected by RIA method as follow.Results The new compound dressing can effectively shorten healing time,which is 25.39 ± 3.12days (the treatment group) comparing with 29.46 ± 4.38days (the injury group) (P ＜ 0.05).And it promotes the formation of skin island in 14days and increase the healing rate(P ＜ 0.05).Besides,the new compound dressing can effectively reduce the total Ca2+ concentration,lower the level of the inflammation factors and the ROS after injury,the results of each period of two groups were significant difference(P ＜0.05).Conclusion New compound dressings can effectively promote skin epithelial repairing,block intra cellular calcium ion channels,reduce the release of inflammation factors and inhibit the reaction of oxidative stress,which provide a new treatment for wound repair.
