Combining Usage of Chemotherapy and Intrapleural Injection with Brucea Javanica Oil in Malignant Pleural Effusion

VernacularTitle:鸦胆子油乳联合全身化疗治疗恶性胸腔积液的疗效观察
Author: Guojun LU ¹ ; Yu ZHANG
Author Information

1. 210029,南京胸科医院呼吸科
Keywords: Brucea Javanica oil; Malignant pleural effusion; Non-small cell lung cancer
From: Journal of Medical Research 2018;47(3):97-99
CountryChina
Language:Chinese
Abstract: Objective To study their efficacy and safety of combining usage of chemotherapy and intrapleural injection with brucea javanica oil in treatment of malignant pleural effusion (MPE).Methods 90 NSCLC patients with MPE in Nanjing Chest Hospital between February 2012 and October 2016 were randomly divided into control and treatment group.Subjects in control group were treated with chemotherapy,while those in treatment group were chemotherapy plus intrapleural injection with brucea javanica oil.Both clinical efficacy and adverse reactions were compared.Results By Combining usage of brucea javanica oil,the treatment group has higher effective rate (86.67％ vs 64.44％),lower pathology rate than control groups (P ＜0.05).The main toxicity,matological toxicity,gastrointestinal tract side reaction fever and chest pain was tolerated.There was no significant difference between two groups(P ＞ 0.05).Conclusion Combining usage of brucea javanica oil and chemotherapy in treatment of MPE was safe and effective,which can remarkably inhibit the growth of tumor,promote pleural adhesions and relief symptom.