A Primary Study of Serum Metabonomic in Patients with Paroxysmal Atrial Fibrillation
10.11969/j.issn.1673-548X.2018.03.012
- VernacularTitle:阵发性心房颤动患者血清代谢组学初步研究
- Author:
Yang PAN
1
;
Xiaojun GOU
;
Jian ZHU
Author Information
1. 201999,上海市宝山区中西医结合医院心内科
- Keywords:
Metabolomics;
Serum;
Biomarkers;
Atrial fibrillation
- From:
Journal of Medical Research
2018;47(3):41-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of metabolites in serum of paroxysmal patients with atrial fibrillation based on metabonomics.Methods The metabolites of serum in 15 patients with atrial fibrillation (case group) and 20 healthy subjects (control group) were measured by gas chromatography-mass spectrometry (GC-MS) group.The metabolic profile difference in the two groups was analyzed and compared by orthogonal design method (OPLS).Results The metabolic profile of the control and case groups was significantly distinguished,and 29 statistically significant differences metabolites were identified using commercially available metabolite libraries (such as the Wiley and NIST mass pools) and the standard metabolite library established in our laboratory,The areas under the ROC curve of 29 metabolites were calculated.The area under the curve of glycerol was 0.937,the area under the serine curve was 0.853,the area under the curve of aspartic acid was 0.933,the area of threonine was 0.823,the area of tryptophan was 1.Conclusion There exist differences in serum of sma] l molecular metabolites between patients with atrial fibrillation and normal healthy people.Glycerol,serine,aspartic acid,threonine and tryptophan of serum in patients with atrial fibrillation may be biomarkers of diagnosis of atrial fibrillation.
