Relationship between BMI and Homocysteine, Pregnancy Outcomes in Patients with Gestational Diabetes Mellitus
10.11969/j.issn.1673-548X.2018.01.039
- VernacularTitle:妊娠期糖尿病患者BMI与同型半胱氨酸、妊娠结局的关联性分析
- Author:
Lefeng GUO
1
;
Junhui ZHANG
;
Lei YUN
;
Suqing FENG
Author Information
1. 内蒙古妇幼保健院
- Keywords:
Gestational diabetes mellitus;
Body mass index;
Homocysteine;
Pregnancy outcomes
- From:
Journal of Medical Research
2018;47(1):156-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between body mass index (BMI) and homocysteine,pregnancy outcomes in patients with gestational diabetes mellitus.Methods From Jan,2013 to Oct,2015,120 patients with gestational diabetes mellitus were prospectively enrolled in this study.According to BMI level,all patients were divided into obese group (BMI≥25 kg/m2) and the control group (BMI ＜ 25kg/m2).The main outcome measures included homocysteine and pregnancy outcomes of the both groups.Results When compared with the control group,patients in the obese group got a significantly higher level of homocysteine (11.09 ± 1.91 vs 8.92 ± 1.57μmol/L,P =0.000);and BMI was positively associated with homocysteine (r =0.410,P =0.000).When compared with the control group,patients in the obesity group got a significantly higher rate of cesarean section (30.00％ vs 15 ％,P =0.049);a higher rate of macrosomia (20.00％ vs 5.00％,P =0.027);and a higher level of neonatal weight (3672.15 ± 475.45 vs 3220.93 ± 461.36g,P =0.000).There was no significantly difference between the two groups in weeks of gestation,postpartum hemorrhage,cephalopelvic said,abnormal fetal position,uterine atony,premature rupture of fetal membranes and neonatal asphyxia rate (P ＞ 0.05).Conclusion BMI in patients with gestational diabetes mellitus is positively correlated with homocysteine,cesarean section,macrosomia and neonatal weight.
