Association of the TLR9 gene rs187084 single nucleotide polymorphism with tuberculosis in the Chinese Tibetan population
10.16571/j.cnki.1008-8199.2018.05.009
- VernacularTitle:TLR9基因rs187084单核苷酸多态性与中国藏族人群结核易感性研究
- Author:
Ming-Gui WANG
1
;
Jing WANG
;
Jian-Qing HE
;
Miao-Miao ZHANG
;
Shou-Quan WU
;
Yu WANG
;
Jun LUO
;
Qian-Qian LIU
Author Information
1. 四川大学华西医院呼吸与危重症医学科
- Keywords:
tuberculosis;
toll-like receptor 9;
single nucle-otide polymorphism;
Chinese Tibetan popula-tion
- From:
Journal of Medical Postgraduates
2018;31(5):490-493
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to investigate the correlation between single nucleotide polymorphisms (SNP) of Toll-like receptor 9 (TLR9) and tuberculosis in the Chinese Tibetan population . Methods A total of 613 active tubercu-losis patients and 603 healthy controls were enrolled in this case -control study.Two SNPs in TLR9 (rs187084 and rs5743836) were genotyped using the multiplex ligation detection reaction technique .The association of the SNPs with the susceptibility of TB was inves -tigated using logistic regression analysis . Results There was no statistically significant difference in the allele distribution of rs 187084 G/A between the TB patients and the healthy controls (P=0.668) or correlation between the genotype of rs 187084 and the genetic suscepti-bility of TB ( P >0.05).Dominant, recessive and additive models showed no association of this SNP with TB , either (P >0.05). Conclusion The rs187084 polymorphism of TLR9 is not correlated with the genetic susceptibility of tuberculosis in the Chinese Tibetan population.
