The drug resistant mechanisms and the solving strategies of Carbapenem-resistant Klebsiella pneumonia
10.16571/j.cnki.1008-8199.2018.04.019
- VernacularTitle:耐碳青霉烯类肺炎克雷伯杆菌的耐药机制及治疗策略研究进展
- Author:
Xue YANG
1
;
Lin LIU
Author Information
1. 贵州医科大学
- Keywords:
klebsiella pneumoniae;
carbapenem resistant;
drug resistant mechanisms;
solving strategies
- From:
Journal of Medical Postgraduates
2018;31(4):430-434
- CountryChina
- Language:Chinese
-
Abstract:
Klebsiella pneumoniae(KP)is one of the most common pathogennic bacteria causing severe respiratory infections. Car-bapenem medicine was used as the last line of defense for KP,but in recent years,with widespread use of carbapenem medicine, the resistance to car-bapenem klebsiella pneumoniae(K.pneumoniae Carbapenem-resistant,CRKP)increased and come to the trend of the outbreak.The resistant strains showed a high proportion,variety,wide distribution,and strong drug resistance.In this article,the related literature content of the CRKP mechanism of drug resistance, molecular epidemiology and clinical antibiotic selection are re-viewed,aiming to investigate the molecular characteristics and the related drugs of choice of CRKP,and providing theoretical basis for the reasonable and effective treatments.
