Advances on the effect of post-translational modification on HMGB1 localization
10.16571/j.cnki.1008-8199.2018.02.017
- VernacularTitle:翻译后修饰对高迁移率族蛋白B1定位影响的研究进展
- Author:
Yan-Chen LI
1
;
Xing LIAO
;
Dan WANG
Author Information
1. 赣南医学院第一临床医学院
- Keywords:
high mobility group box 1;
post-translational modification;
location;
translocation;
release;
function
- From:
Journal of Medical Postgraduates
2018;31(2):193-197
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box 1 (HMGB1) is a highly conserved and evolutionarily non-histone chromosomal protein that is modified by different PTMs,such as acetylation,glycosylation,phosphorylation,ADP-ribosylation,methylation and oxidation,which induces HMGB1 translocation to the cytosol or releases to the extracellular secretion following various stimuli,and its biological function also changes with the location change.This review aims to summarize the structure,the effect of PTMs on HMGB1 location and function.
