Research progress of GLUT1 in urinary tumor
10.16571/j.cnki.1008-8199.2018.01.022
- VernacularTitle:葡萄糖转运蛋白1在泌尿系肿瘤中的研究进展
- Author:
Lei-Hong DENG
1
Author Information
1. 南昌大学江西医学院
- Keywords:
urinary tract neoplasms;
glucose transporters protein 1;
gene therapy target
- From:
Journal of Medical Postgraduates
2018;31(1):104-108
- CountryChina
- Language:Chinese
-
Abstract:
Glucose transporters protein (GLUTs) is the main carrier of glucose transport in mammalian cells, in which GLUT1 is the most widely distributed in glucose transporter in vivo. Studies have shown that GLUT1 has abnormally high expression in urinary tract tumors such as renal cell carcinoma,prostate cancer,bladder cancer and nephroblastoma,cleading to increased intracellu-lar glucose uptake,which is closely related to tumor occurrence,evolution,invasion,prognosis and drug resistance. As a new target of tumor therapy,GLUT1 has attracted extensive attention. This review summarizes the recent advances on the expression of GLUT1 in tumor and its mechanism,which can provide a new perspective for the treatment and prognosis evaluation of tumor.
